PAPERS

Advanced therapy manufacturers have taken the head start that Nature’s given them and used developments in genetic engineering, computational biology and bioinformatics to perfect the viral particle as a vector for therapeutic DNA and hasten the clinical success of...

CAR T cell therapies have been met by numerous scientific, logistical, and manufacturing challenges, and yet, a shared determination to produce readily available, cost-effective CAR T cell therapies is more present than ever.

Sophie Lutter, OXGENE, looks at the important role antibody therapeutics have to play and how, as the world has looked for Covid-19 treatments in the last year, their significance has been noted. As the world continues to adjust and respond to the impact of the Covid-19...

A new mammalian display platform enhances antibody discovery for challenging protein targets. Membrane proteins are important therapeutic targets as they transduce signals into cells, transport molecules, bind to surfaces, and catalyze reactions. However, researchers...

Viral vices have been center stage throughout the ongoing pandemic, but to the everyday scientist, viruses are essential tools in the research toolbox. Viruses are vectors not of disease, but of gene-edited transcripts, candidate genes, and potential therapeutics. These...

Identification and affinity maturation of antibodies against membrane proteins in their native configuration remains challenging. Here, OXGENE use their SLIM display antibody discovery platform for a affinity maturation project using a parental antibody against a GPCR...

I founded the company in 2011, based on my own experience in the lab, which identified that molecular biologists needed a quicker, easier, and more reliable way to engineer DNA. I wanted to create a system that meant scientists would be able to assemble DNA in the same way...

Qian Liu is a Senior Group Leader at OXGENE™ (Oxford, UK) and Corinne Branciaroli is Group Leader of the Viral Cell Line Development team at OXGENE. Qian joined OXGENE in 2017 following a PhD and two postdocs focused on regenerative medicine. When Qian first joined OXGENE,...

Lentiviral vectors are often a popular choice for transient transfection; however, they can be expensive, difficult to reproduce at larger scales and can result in contamination of the lentiviral preparation. Packaging and producer cell lines for lentiviral production...

In 1970, Feidman and Roblin published a seminal paper in Science proposing that genetic diseases could be cured by using 'good' DNA to replace the 'defective' DNA causing genetic disease. This idea - the central tenet of gene therapy - remains sound but has proved...