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10 March 2021

Identifying Antibodies that Target Membrane Proteins in Their Native Conformations

OXGENE

Sponsored/TheScientist/10 March 2021

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Abstract

A new mammalian display platform enhances antibody discovery for challenging protein targets.

Membrane proteins are important therapeutic targets as they transduce signals into cells, transport molecules, bind to surfaces, and catalyze reactions. However, researchers face challenges when developing antibody-based drugs targeting membrane proteins, such as monoclonal antibody and chimeric antigen receptor (CAR) T cell therapies, because the proteins are embedded within the membrane, leaving only a few surface-exposed epitopes accessible to therapeutics.

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