CAR-T cell therapies have demonstrated tremendous success in relapsed or refractory haematological
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malignancies. Now therapeutics companies and academics alike are racing to break through the barrier of solid
tumours, taking imaginative approaches to overcome the numerous obstacles in the way of turning a hugely
variable starting material into an armed and precisely targeted weapon against cancer. As of Q3 2020, there were
over 500 clinical trials evaluating CAR-T cell therapies worldwide (as registered at clinicaltrials.gov, Q3 2020)¹.