PAPERS

Insights into how to overcome common hurdles to manufacturing and developing gene therapy, including overcoming a reliance on plasmid technology, streamlining manufacturing processing, and more.

Viruses have evolved to invade host cells and hijack their cellular machinery to direct the replication and transcription of their own genomes. While these properties make viruses dangerous pathogens, they also make them ideal couriers for getting new DNA into a host cell...

Viruses invade host cells and hijack their cellular machinery to direct the replication and transcription of their own genome. This makes them dangerous pathogens as well as ideal couriers to transport new DNA into a host cell and ensure that it’s transcribed, reports Dr...

Advanced therapy manufacturers have taken the head start that Nature’s given them and used developments in genetic engineering, computational biology and bioinformatics to perfect the viral particle as a vector for therapeutic DNA and hasten the clinical success of...

CAR-T cell therapies have demonstrated tremendous success in relapsed or refractory haematological malignancies. Now therapeutics companies and academics alike are racing to break through the barrier of solid tumours, taking imaginative approaches to overcome the numerous...

CAR T cell therapies have been met by numerous scientific, logistical, and manufacturing challenges, and yet, a shared determination to produce readily available, cost-effective CAR T cell therapies is more present than ever.

Sophie Lutter, OXGENE, looks at the important role antibody therapeutics have to play and how, as the world has looked for Covid-19 treatments in the last year, their significance has been noted. As the world continues to adjust and respond to the impact of the Covid-19...

A new mammalian display platform enhances antibody discovery for challenging protein targets. Membrane proteins are important therapeutic targets as they transduce signals into cells, transport molecules, bind to surfaces, and catalyze reactions. However, researchers...

Viral vices have been center stage throughout the ongoing pandemic, but to the everyday scientist, viruses are essential tools in the research toolbox. Viruses are vectors not of disease, but of gene-edited transcripts, candidate genes, and potential therapeutics. These...

Identification and affinity maturation of antibodies against membrane proteins in their native configuration remains challenging. Here, OXGENE use their SLIM display antibody discovery platform for a affinity maturation project using a parental antibody against a GPCR...